“Bad Neighbours” in the US, sold $51m (£30.2m) worth of tickets over the weekend.
The Amazing Spider-Man 2, starring British actor Andrew Garfield, took $37m (£22m), according to estimates.
Paul Dergarabedian, senior media analyst for box-office tracker Rentrak said: “You don’t expect a comedy to be able to unseat an epic blockbuster, but historically it happens more than you think.”
The sequel to The Amazing Spider-Man, which sees Garfield reprise his role as the web-slinging superhero, has made more than $550m (£326m) in worldwide ticket sales so far.
