The Guardians vs Cardinals live stream guide is drawing attention as St. Louis prepares to host Cleveland in the first meeting between the two clubs this season. The three-game series opens on Monday, April 13, 2026, at Busch Stadium in St. Louis, Missouri.
First pitch is set for 7:45 p.m. ET. Fans can watch the game through MLB.TV and the broadcasting platforms operated by both franchises.
Monday’s matchup opens an interleague series between two teams that have shown flashes of strong early-season form. Cleveland entered the game with a 9-7 overall record and a 5-5 road record. St. Louis, meanwhile, was 8-7 overall and had gone 3-0 in games where it out-hit opponents.
The game will take place at Busch Stadium, giving the Cardinals home-field advantage for the opener. That setting should add extra energy to the first major face-off between the teams this year.
Players to Watch in Guardians vs Cardinals Opener
Several players to watch on both sides. For St. Louis, Hordan Walker leads the team with nine extra-base hits, including two doubles and seven home runs. Ramon Urias has also contributed recently, going 6 for 26 over the last 10 games with two doubles, two home runs and four RBIs.
For Cleveland, Chase DeLauter leads with five home runs and owns a .680 slugging percentage. Angel Martinez has also been productive, going 12 for 35 over his last 10 games with two doubles, one home run and six RBIs.
This game as the first big meeting of the season between the Cardinals and Guardians. With both teams carrying winning records and key hitters in form, the opener could set the tone for the rest of the series.
Fans looking for viewing information should focus on the start time, venue and streaming access, while also keeping an eye on the featured hitters who could shape the result.
