The Bunnie Xo GLP-1 suicidal ideation warning has intensified debate over the mental health risks linked to popular weight-loss medications, especially as Serena Williams has publicly praised their benefits.
GLP-1 drugs such as Ozempic and semaglutide have become widely discussed in Hollywood and beyond. While many celebrities describe positive health changes, Bunnie Xo shared a deeply troubling experience that she says nearly cost her her life.
In a recent interview, Bunnie Xo, host of the “Dumb Blonde” podcast and wife of singer Jelly Roll, described December 2025 as “one of the darkest times” of her life. She said she experienced suicidal ideation after starting a GLP-1 medication.
“I was proud of the fact that I only had anxiety. I had never had depression,” she explained. However, she said the medication triggered a state she had never faced before. “When you get hit with suicidal ideation and visions, oh, it was horrible.”
Bunnie Xo GLP-1 Suicidal Ideation Warning
Bunnie Xo said she began using the drug due to a family history of diabetes and difficulty managing insulin levels. Yet she described her body’s response as devastating.
“You’d rather have anxiety because you want to be afraid of dying,” she said. “You don’t want to have depression because, literally, you don’t care if you want to die. So yes, it was something really dark.”
She emphasised that she is now doing well. Nevertheless, she urged others to speak openly about similar experiences.
Bunnie Xo Went Through a ‘Bout of Suicidal Ideation’ While Taking a GLP-1 (Exclusive) https://t.co/naBNZxIP7K
— People (@people) February 12, 2026“I really think people need to talk more about this,” she said. “Don’t make a permanent decision based on a temporary emotion because this will pass.”
Her comments highlight the importance of discussing both the physical and psychological effects of GLP-1 medications.
Serena Williams Shares Positive Experience
In contrast, Serena Williams has spoken publicly about the benefits she experienced. In a past interview with People, the tennis legend said she felt healthier and lighter after using a GLP-1 medication.
“I feel healthier. I feel lighter. I feel great,” she said. She also noted improvements in her health numbers.
Read: Serena Williams Faces Criticism for Weight-Loss Drug Endorsement
Williams even appeared in a commercial during a recent Super Bowl broadcast, further validating her positive experience. The difference between these two accounts reflects the varied responses individuals may have when using such treatments.
Other Celebrities on GLP-1 Medications
Several public figures have openly discussed their experiences with GLP-1 medications, helping reduce stigma around medical weight management.
- Whoopi Goldberg shared on The View that she used Mounjaro after her weight reached nearly 300 pounds.
- Oprah Winfrey defended the use of medication as a legitimate health tool.
- Kelly Clarkson clarified that she uses a prescribed medication, though not Ozempic.
- Amy Schumer has spoken about both early side effects and later benefits.
These accounts show a range of outcomes. While some report improved metabolic health, others highlight significant mental health concerns.
As discussion around GLP-1 medications grows, experts continue to stress that medical decisions should involve professional guidance. Public conversations like these underscore the need for awareness about potential side effects and individualised care.
