Since the twin Viking spacecraft landed on the red planet in 1976, Nasa has relied on the same parachute design to slow landers and rovers after piercing through the thin Martian atmosphere.
The $150 million experimental flight tests a novel vehicle and a giant parachute designed to deliver heavier spacecraft and eventually astronauts.
Viewers around the world with an internet connection followed portions of the mission in real time thanks to cameras on board the vehicle that beamed back low-resolution footage.
After taking off at 11:40 a.m. from the Pacific Missile Range Facility on the Hawaiian island of Kauai, the balloon boosted the disc-shaped vehicle over the Pacific. Its rocket motor should then ignite, carrying the vehicle to 34 miles (55 kilometers) high at supersonic speeds.
The environment this high up is similar to the thin Martian atmosphere.